Genetic Differences in
Immune Reactions to Radiation Exposure in Humans and Experimental
Animals
V. I. Konenkov1
and V. A. Trufakin1
(1) |
Institute of Clinical
Immunology; Institute of Physiology, Siberian Division of the Russian
Academy of Medical Sciences, Novosibirsk |
Abstract Examination of
populations living in regions of fallout radiation revealed changes in
the distribution of HLA genes not only in irradiated individuals, but
also in their children and grandchildren. Combined irradiation of
inbred mice in comparable doses showed that H-2 genes determine immune
reactions in animals and their offspring to radiation. Our results
indicate that the immune system in mammals is immunogenetically
regulated by low-dose radiation.
radiation - immune
system - major histocompatibility complex genes