* DNA damage, cell kinetics
and ODC activities studied in CBA mice (14/9/02)
Tramès per Klaus Rudolph (Citizens'
Initiative Omega)
In Vivo 1999 Nov-Dec;13(6):507-13
DNA damage, cell kinetics and ODC activities studied in CBA mice exposed
to electromagnetic fields generated by transmission lines.
Svedenstal BM, Johanson KJ, Mattsson MO, Paulsson LE. Department of Radioecology,
Swedish University of Agricultural Sciences, Uppsala, Sweden. svedenstal@delta.telenordia.se
CBA mice were exposed outdoors to 50 Hz electromagnetic fields (EMF),
with a flux density of about 8 microT rms (root mean square), generated
by a 220 kV transmission line. Assays were performed in order to investigate,
the possible genotoxic effects after 11, 20 and 32 days of exposure, as
well as the effects on body weight, leukocytes, erythrocytes, and the
level of ornithine decarboxylase (ODC) activity in spleen and testis.
DNA migration was studied on brain cells by single cell electrophoresis
(comet assay). After 32 days of exposure a highly significant change of
the tail/head ratio of the comets was observed (p < 0.001), showing
DNA-damage. Further, a decreased number of mononuclear leukocytes (0.02
< p < 0.05) was observed in mice EMF-exposed for 20 days. In summary,
our data indicate that transmission lines of this type may induce genotoxic
effects in mice, seen as changes in the DNA migration. These results might
have an important implication for health effects.
PMID: 10757046 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10757046&dopt=Abstract
Message from Joanne Mueller (summary)
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