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Betreff:
Alzheimers...memory
improvement re histone acetylation..... |
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Von: JCMPelican @aol.com |
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Datum: Fri, 8 Jun 2007 11:41:57 EDT |
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Re: Alzheimers....memory improvement re
histone acetylation.....
I am forwarding separately information
regarding a new study re histone acetylation as well as relevant studies
from 1998 and 2002.
Assoc. Prof. Olle Johansson has conducted
hundreds of EMF studies that relate either directly or indirectly to findings re
immune deficiencies as well as Alzheimers and other health
problems. As most persons involved in reviewing journal articles re
effects of EMF/EMR know, "histamine" plays a very important role.
Here are a couple of comments from
previously posted information on Omega site below:
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http://omega.twoday.net/stories/1078116/
Portions of email exchanges between Assoc.
Prof. Olle Johansson and Joanne Mueller (2005) re skin problems and lack of IgE findings in EHS
(electrohypersensitive) patients and comparisons re rare IGG subclass
deficiencies:
"........We would favour studies of
electromagnetic fields' interaction with mast cell release of histamine and
other biologically active substances, studies of lymphocyte viability as well
as studies of the newly described serotonin-containing melanocytes.......as well
as other markers for cell traffic, proliferation and inflammation.......such
scientific work may lay a firm foundation for necessary adjustment of
accessibility, thus helping and supporting all persons with the impairment
electrohypersensitivity......." .olle johansson Oct. 2005
" ........ a 'very important evaluation' that will hopefully go
a long way toward moving away from "allergic-type sensitivity" to
deal with the "real issue of EMF/EMR-induced toxicity" -- or "the poisoning" that results from chronic,
prolonged exposures to even low levels of electromagnetic radiation
pollution......!!!! joanne mueller Oct. 2005
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See also list of references:
http://www.icems.eu/docs/Johansson_papers.pdf
Assoc. Prof. Olle Johansson, Karolinska
Institute, Stockholm Sweden
PUBLISHED PAPERS
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I call specific attention to the following
study re the need to consider all EMF/EMR exposures as contributors to the sort
of stresses that are reported to be associated with memory decline:
Hallberg Ö, Johansson O, "Alzheimer
mortality - why does it increase so
fast in sparsely populated areas?", Europ Biol Bioelectromag 2005; 1:
225-246
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The knowledge exists -- studies support
what is known and future studies will provide even more conclusive
results. My appeal continues for the publicity needed to
"fuel the fires" that will help generate the much-needed funding for
Assoc. Prof. Olle Johansson in turning these tragic events
around!!!!
Take care everyone
- Joanne
Joanne C. Mueller
Guinea Pigs R Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota 55448-2127 USA
Phone: 763-755-6114
Email: jcmpelican@aol.com (6-08-07)
All truth goes through three stages: first
it is ridiculed:
then it is violently opposed: finally it is accepted as self evident. -
Schopenhauer
"The things that will destroy us are: politics without principle;
pleasure without conscience; wealth without work; knowledge without character;
business without morality; science without humanity; and worship without
sacrifice."
--Mahatma Gandhi
Alz...histone acetylation...2007 Von: JCMPelican@aol.com Datum: Fri, 8 Jun 2007
10:32:22 EDT An: JCMPelican@aol.com
Journal Watch General Medicine Alert jw-general-medicine@alerts.stanford.edu
General Medicine for June 7, 2007 Drugs and Mental Exercises Enhance Recovery
of Lost Memories in Mice
http://general-medicine.jwatch.org/cgi/content/full/2007/607/2?q=etoc
Summary and Comment | Subscription Required
The key to both approaches was an increase in histone acetylation.
By Anthony L. Komaroff, MD
June 7, 2007
Covering: Fischer A et al. Nature 2007 May 10; 447:178-82
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From: JCMPelican@aol.com |
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Date: Fri, 8 Jun 2007 10:29:45 EDT |
GENES &
DEVELOPMENT -
Vol. 12, No. 5, pp. 599-606, March 1, 1998
PERSPECTIVE
Histone acetylation and transcriptional regulatory mechanisms
Department of
Biological Chemistry and Molecular Pharmacology, Harvard Medical School,
Boston, Massachusetts 02115 USA
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Introduction |
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More
than 30 years ago, Vincent Allfrey proposed that histone acetylation was
associated with transcriptional activity in eukaryotic cells
(Allfrey et al. 1964
;
Pogo et al. 1966
).
Subsequently, acetylated core histones were shown to preferentially
associate with transcriptionally active chromatin (Sealy and
Chalkley 1978
;
Vidali et al. 1978
;
Hebbes et al. 1988
).
Acetylation occurs at lysine residues on the amino-terminal tails of
the histones, thereby neutralizing the positive charge of the
histone tails and decreasing their affinity for DNA (Hong et al.
1993
).
As a consequence, histone acetylation alters nucleosomal
conformation (Norton et al. 1989
),
which can increase the accessibility of transcriptional regulatory proteins
to chromatin templates (Lee et al. 1993
;
Vettese-Dadey et al. 1996
).
Taken together, these observations suggested how histone acetylation
could result in increased transcriptional activity in vivo. However,
there was essentially no information about the cause and effect
relationship between histone acetylation and transcriptional
activity or about the underlying molecular mechanisms.......
.[ Alz
file ....this is a lengthy, very important article -- review in
conjunction with other articles re histone acetylation and memory improvement
......jcm....6-08-07.....]
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Alz...HISTONE
ACETYLATION (imprv memory).... |
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From: JCMPelican@aol.com |
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Date: Fri, 8 Jun 2007 10:18:07 EDT |
EMBO reports 3, 3, 224–229
(2002) doi:10.1093/embo-reports/kvf053 Histone acetylation facilitates RNA polymerase II transcription of the
Drosophila hsp26 gene in chromatin |
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Karl P. Nightingale1, Ralf E. Wellinger2,
Jose M. Sogo2 and
Peter B. Becker1 |
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1 Gene Expression Programme,
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg,
Germany |
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Abstract |
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A number
of activators are known to increase transcription by RNA polymerase (pol) II
through protein acetylation. While the physiological substrates for
those acetylases are poorly defined, possible targets include general
transcription factors, activator proteins and histones. Using
a cell-free system to reconstitute chromatin with
increased histone acetylation levels, we directly tested for a causal
role of histone acetylation in transcription by RNA pol II. Chromatin,
containing either control or acetylated histones, was reconstituted to
comparable nucleosome densities and characterized by electron microscopy
after psoralen cross-linking as well as by in vitro transcription. While
H1-containing control chromatin severely repressed transcription of our model
hsp26 gene, highly acetylated chromatin was significantly less
repressive. Acetylation of histones, and particularly of histone
H4, affected transcription at the level of
initiation. Monitoring the ability of the transcription
machinery to associate with the promoter in chromatin, we
found that heat shock factor, a crucial regulator of heat
shock gene transcription, profited most from histone acetylation.
These experiments demonstrate that histone acetylation can modulate activator
access to their target sites in chromatin, and provide a
causal link between histone acetylation and enhanced transcription initiation
of RNA pol II in chromatin. |
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Keywords: chromatin, heat shock, histone
acetylation, nucleosomes, transcription |
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[ ..... Alzheimers
file notes: review re following study
"recovery lost memories in mice" (subscr required) when
accessed......emphasis in article "Histone acetylation" -- EMBO reports 3, 3, 224–229
(2002)
doi:10.1093/embo-reports/kvf053
added jcm 6-08-07..... ]
Drugs and Mental
Exercises Enhance Recovery of Lost Memories in Mice
Summary and Comment | Subscription Required
The key to both approaches was an increase
in histone acetylation.
By Anthony L. Komaroff, MD
June 7, 2007
Covering: Fischer A et al. Nature 2007 May 10; 447:178-82