Betreff: White matter changes re treatment for ALL...."hypersintensity..."
Von: JCMPelican
Datum: Fri, 15 Dec 2006 12:01:04 EST
An: olle.johansson

Dear Olle:   This is one item I located regarding white matter hyperintensities that occur as result of chemotherapy and radiation treatments.
Since "white matter hyperintensities" are also identified in many diseases such as immune deficiency, M.S., Alzheimers and migraine, AND such exposures are related to nonionizing radiation (low level EMF/EMR chronic, prolonged "toxic exposures), this information re treatment for ALL (Leukemia) is further confirmation that health effects are "identical" whether one is chronically exposed to low levels of chemicals, ionizing radiation or non-ionizing radiation. 
How much longer are scientists going to be able to get away with saying effects are "biological" without admitting such changes are indicators of "serious health effects?"   Hopefully funding will soon come your way to prove once and for all that white blood cell changes are identical and dangerous regardless whether due to chemicals,  low level ionizing radiation or low level non-ionizing radiation "chronic, prolonged exposures......"      Best wishes and take care  -  Joanne
Joanne C. Mueller
Guinea Pigs R Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota  55448-2127 USA
Phone:   763-755-6114
Email:  (12-15-06)

"No substance is a poison by itself. It is the dose that makes a substance a poison..."   Paracelsus (1493-1541)

Betreff: White matter changes re treatment for ALL...."hypersintensity..."
Von: JCMPelican
Datum: Sun, 10 Dec 2006 02:12:05 EST

[ jcm file note 12 10 06......A long study re children with leukemia and resultant white matter changes and other changes due to chemotherapy and radiation.....]
Published online before print October 23, 2003, 10.1148/radiol.2293021550

White Matter and Cerebral Metabolite Changes in Children Undergoing Treatment for Acute Lymphoblastic Leukemia: Longitudinal Study with MR Imaging and 1H MR Spectroscopy1

Winnie C. W. Chu, FRCR, Ki-wai Chik, MRCP, Yu-leung Chan, FRCR, David K. W. Yeung, PhD, Derek J. Roebuck, FRCR, FRACR, Robert G. Howard, FRANZCR, FHKCR, Chi-kong Li, FRCP and Constantine Metreweli, FRCR, FRCP

1 From the Depts of Diagnostic Radiology and Organ Imaging (W.C. W.C., Y.L.C., R.G.H., C.M.), Paediatrics (K.W.C., C.K.L.), and Clinical Oncology, Medical Physics Div (D.K.W.Y.), Chinese Univ of Hong Kong, Prince of Wales Hosp, 30–32 Ngan Shing St, Shatin, Hong Kong SAR, China; and Dept of Radiology, Great Ormond Street Hospital for Children, London, England (D.J.R.). Received Dec 3, 2002; revision requested Feb 6, 2003; final revision received Apr 11; accepted May 20. Address correspondence to W.C.W.C. (e-mail:

PURPOSE: To assess the development of white matter and cerebral metabolite changes during and after treatment in children with acute lymphoblastic leukemia.

MATERIALS AND METHODS: Twenty-three children (10 boys, mean age of 6.3 years; 13 girls, mean age of 6.6 years) with acute lymphoblastic leukemia were examined prospectively with magnetic resonance (MR) imaging and MR spectroscopy at 0, 8, and 20 weeks and 1, 2, and 3 years after diagnosis. White matter changes were diagnosed on the basis of hyperintense abnormalities on T2-weighted MR images. Single-voxel hydrogen 1 MR spectroscopy results from the right frontoparietal region of 21 children who received intravenous high-dose methotrexate were analyzed for cerebral metabolite changes. Multilevel models were used to assess the change in metabolites from baseline levels at subsequent follow-up..........

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[several paragraphs skipped between above and paragraph below....jcm 12 10 06....]

High-dose methotrexate is effective for CNS prophylaxis in children with acute lymphoblastic leukemia, but the treatment is known to cause white matter abnormality (leukoencephalopathy), detected as regions of hyperintensity on T2-weighted magnetic resonance (MR) images (9,10). The reported incidence of white matter abnormality shown in the early posttreatment period (11) is much higher compared with that in the later stages (1214). Most of these changes are transient in nature, and they disappear within 12–24 months with negative follow-up imaging results (12).

[jcm note 12 10 06......this article is very long... only above two paragraphs copied.....]