Betreff: follicles...1985....
Von: JCMPelican
Datum: Wed, 7 Mar 2007 23:47:15 EST

Cell Death (Apoptosis) in Hair Follicles and Consequent Changes in the Width of Hairs after Irradiation of Growing Follicles

Author: Potten C.S.1

Source: International Journal of Radiation Biology, Volume 48, Number 3, September 1985, pp. 349-360(12)

Publisher: Taylor and Francis Ltd

Irradiation of anagen (growing) hair follicles results in a dose-dependent increase in the number of histologically identifiable fragments of dead cells (apoptotic fragments). The incidence of apoptotic fragments is linearly related to dose, increasing at a rate of 2fragments per follicle section per Gy. The effects of doses of 0y can be easily detected. Subjective attempts to associate clusters of fragments with dead or dying cells suggests that the number of fragments per cell increases with dose (about 1 fragments per cell after 1 Gy to about 2ragments per cell after 5 Gy). There is a natural incidence of cell death in controls (0 0fragments per follicle section with about 1ragments per dead or dying cell). Damage to the follicle cells is expressed in the differentiated product of the follicle, the hair, by a reduction in width. This is probably the cellular basis for the production of dysplastic hairs. The hair width has been measured and is reduced by about 7 per cent for every gray of radiation. The value of the hair and hair follicles as potential biological dosimeters is discussed.

Keywords: hair damage, hair dysplasia, hair follicle damage,

Document Type: Research article

Affiliations: 1: Paterson Laboratories, Christie Hospital & Holt Radium Institute, Withington, Manchester M20 9BX, U.K.;jsessionid=5apagd67kt179.alice