Betreff: Fwd: Leukemia....NEED TO MIMIC HUMAN EXPOSURES.....EPRI &Harvard..2003
Von: JCMPelican
Datum: Wed, 14 Feb 2007 00:16:05 EST

Dear Dr. Carlo and Dr. Johansson:    The information regarding the meeting between persons from Electric Power Research Institute and Harvard (2003), is "a surprise to me!!!"  
Does anyone know what they are doing to "mimic human exposures?" 
I continue to seek funding for Olle Johansson to do the sort of studies that do "mimic human exposure" -- identifying white blood cell changes that are well-known to be "markers for irradiation" (whether the exposure is low level ionizing or low level nonionizing radiation -- chronic, prolonged exposures) but in the meantime, wanted to emphasize that constant review of available epidemiological studies always point to "confounding," and many reports such as this one re Leukemia (that "followed release of 2002 EMF California Report") confirm the need to replicate "real human exposure."
Many adverse cellular changes occur prior to the development of Leukemia as well as many adverse health symptoms including but not limited to poor quality sleep, chronic ear infections, chronic sinus infections, asthma/hyperactive airway problems, gastrointestinal problems, etc., etc. 
As we know, the best way to do that is to start with the most obvious, potentially harmful "chronic, prolonged exposures" which, for children, in particular (cell phones are in major category of concern but most Leukemia cases in children precede ages when cell phone use is applicable) --  we can no longer afford not to make "nighttime electrical items -- electric meters, gas meters, clocks, fans, lights with dimmer switches, touchlamps, security alarms, power supply boxes for cordless phones -- really anything with a motor or transformer that might be close to a bed -- "a TOP PRIORITY!!!"
A "focus" on that which causes Leukemia will provide details relating to every health problem there is.  All are causally related to chronic inflammation and immune dysfunction!!!
Infants and toddlers are dying -- they can't wait for studies that take funding that is impossible to obtain due to all of the greed and deception that prevails..........
Children depend upon their parents hearing announcements that electrical items should be moved away from beds while awaiting further studies!!!
If there is anything that can be done at the upcoming meetings toward releasing "precautionary announcements" to the public, I will be extremely relieved to hear about it!!!    Best wishes and take care  -  Joanne
Joanne C. Mueller
Guinea Pigs R Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota  55448-2127 USA
Phone:   763-755-6114
Email:   (2-13-07)
"No substance is a poison by itself. It is the dose that makes a substance a poison..."  Paracelsus (1493-1541)

Betreff: Leukemia....NEED TO MIMIC HUMAN EXPOSURES.....EPRI &Harvard..2003
Von: JCMPelican
Datum: Tue, 13 Feb 2007 13:36:24 EST

Childhood leukemia: electric and magnetic fields as possible risk factors - Workshop Summary

Numerous epidemiologic studies have reported associations between measures of power-line electric or magnetic fields (EMFs) and childhood leukemia. The basis for such associations remains unexplained. In children, acute lymphoblastic leukemia represents approximately three-quarters of all U.S. leukemia types. Some risk factors for childhood leukemia have been established, and others are suspected. Pathogenesis, as investigated in animal models   [rats and mice???  jcm file note 2-13-07......]  , is consistent with the multistep model of acute leukemia development. Studies of carcinogenicity in animals, however, are overwhelmingly negative and do not support the hypothesis that EMF exposure is a significant risk factor for hematopoietic neoplasia. We may fail to observe effects from EMFs because, from a mechanistic perspective, the effects of EMFs on biology are very weak. Cells and organs function despite many sources of chemical "noise" (e.g., stochastic, temperature, concentration, mechanical, and electrical noise), which exceed the induced EMF "signal" by a large factor. However, the inability to detect EMF effects in bioassay systems may be caused by the choice made for "EMF exposure." "Contact currents" or "contact voltages" have been proposed as a novel exposure metric, because their magnitude is related to measured power-line magnetic fields. A contact current occurs when a person touches two conductive surfaces at different voltages. Modeled analyses support contact currents as a plausible metric because of correlations with residential magnetic fields and opportunity for exposure. The possible role of contact currents as an explanatory variable in the reported associations between EMFs and childhood leukemia will need to be clarified by further measurements, biophysical analyses, bioassay studies, and epidemiology. Key words: childhood leukemia, contact currents, contact voltages, electric and magnetic fields, EMF, review.

Whether health risks result from exposure to power-line electric or magnetic fields (EMFs) remains unclear. Epidemiologic studies have repeatedly shown small associations between measures of residential power-line magnetic fields and childhood leukemia. The possibility that these associations are caused by bias or confounders, however, cannot be ruled out (Savitz 2003). In addition, extensive investigations in animals at much higher levels of EMFs have not demonstrated adverse effects (Boorman et al. 2000). Recently, the International Agency for Research on Cancer (IARC 2002) designated EMFs as a class 2B carcinogen ("possibly carcinogenic"), based on "consistent statistical associations of high-level residential magnetic fields with a doubling of the risk of childhood leukemia." The California Department of Health Services (CADHS 2002) recently issued a report concluding that "EMFs can cause some degree of increased risk of childhood leukemia, adult brain cancer, Lou Gehrig's disease, and miscarriage." Hence, the question of whether electric-power use has a possible role in childhood leukemia risk remains in the forefront of concern.

To assess past research and suggest future directions in the area of childhood leukemia and EMFs, the Electric Power Research Institute and the Harvard School of Public Health sponsored a workshop titled "Childhood Leukemia: Added Risk from the Use of Electricity?" on 8 November 2001, in Lexington, Massachusetts. This workshop brought together a number of experts.

The epidemiologic associations reported between EMFs and childhood leukemia remain unexplained. Integrating all the lines of evidence presents a challenge to accurately evaluating potential health effects from EMFs. Epidemiologic results, when available, often predominate over rodent bioassay and other laboratory data in hazard identification and risk assessment. However, the epidemiology studies of EMFs and childhood leukemia, all of case-control design, pose several issues, and the link between EMFs and leukemia has not been supported by laboratory data. In many of the epidemiology studies, the small proportion of the study population classified as receiving high exposure levels limits the precision of the effect estimate. In addition, confounding and differential selection and participation of controls by attributes associated with exposure can lead to biased effect estimates (Ahlbom et al. 2000; Hatch et al. 2000). Finally, the relevant exposure metric is not known; thus, it has not been possible for epidemiologists to quantify EMF exposure appropriately in the study populations. Experimental approaches also have limitations, such as a) requiring high-dose to low-dose extrapolation, b) requiring interspecies extrapolation, c) using "pure" EMF signals of specific frequency and field strength that may not mimic real human exposures, and d) being subject to practical and logistic bounds on study size (statistical power). Epidemiologists have been hampered because experimental studies of EMFs have not identified biologic mechanism(s) that could serve as the basis for designing new studies. The goal of the workshop described here was to review the science and consider new directions for EMF research in the areas of epidemiology, exposure metrics, animal studies, and biophysics.

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[Emphasis added by Joanne Mueller .......note particularly the comment  "....MAY NOT MIMIC REAL HUMAN EXPOSURES    "      The critical need to "focus" on close nightime exposures"   has been obvious for a long time........under above circumstances, results in animals as well as humans are plain as day!!!    -- -- that rats and mice should not be used as EMF test subjects but rather, guinea pigs, who are biologically closer to humans due to adrenal glands being larger in proportion to their bodies as in humans, as well as fact they produce cortisol as do humans (rats and mice produce corticortoids) and are "radiosensitive.".    See stress hormone article (not about EMF exposure but "stress" is immediate change/early change regarding low level EMF exposures thus importance of reviewing stress article below -- American Psychological Association Online  - -
Volume 36, No. 1 January 2005


  To the extent that these findings generalize to the kinds of stressors and symptoms that humans experience, they'll provide valuable mechanistic insights and potentially important clinical implications."

Gregory Miller
University of British Columbia


Science Watch
Hard-hitting hormones: The stress-depression link

Stress-hormone injections result in depressive behavior affecting male rats more than females ones.

Print version: page 24

Chronic stress has long been shown to fuel depression, but how?

........continued jcm comments:   additional proof that mice and rats are not good subjects when evaluating human EMF exposures --  adrenal gland function eval when it comes to "radio-sensitive subjects" such as guinea pigs and humans simply can not be reliably compared to studies using rats and mice in the first instance but when adding the fact that there are significant variables between male and female rats, it is obvious that reviews of "any inconclusive EMF studies or those w/only negative findings" must include significance of male to female ratio of test subjects.........  jcm file notes 2-13-07.....]