This is a recent study by Dr. Russel Reiter, et al re melatonin as
a free radical scavenger (February 2007) -- http://www.actabp.pl/pdf/1_2007/1.pdf
I think the references to "physiological situations" is very
meaningful particularly since "non-visible electromagnetic radiation"
is mentioned as possibly affecting 24-hour circadian
I am concerned that "light" is specifically mentioned but no
example is provided to explain what "non-visible electromagnetic
radiation" exposures might be. Perhaps the complete study
includes an explanation?
A review of Dr. Reiter's book, titled "Melatonin," published in
1995, while reviewing this abstract and also another study of Dr.
Reiter's in 2000, re melatonin protection against effects of
ionizing radiation -- http://www.freeradicalscience.com/showabstract.php?pmid=10998194
makes me wonder why Dr. Reiter's book has never been
updated. The book mentions over 130 more studies (not
necessarily Dr. Reiter's, but.......) were being planned.
Chapter 14 in Dr. Reiter's book, "Melatonin" is titled: "
"The Elusive Enemy -- Electromagnetic Fields....How to protect yourself
from melatonin-lowering EMFs....." Among
other important facts, this chapter explains in detail why bedroom
exposures should be reduced -- he refers specifically to electric
blankets, electric clocks, transformers, main power supply to home,
wiring and more.
There is so much valuable information in this book that I had to
stop highlighting and clipping pages (long ago) for fear the extra
stress on so many pages might cause the book to fall apart. I
don't recall exactly when I learned that the book is no longer in
print, but I was and still am "very distressed" that such a valuable
piece of work explaining the importance of melatonin, the vital roles
it plays -- including important information regarding autism and
Alzheimers, breast cancer and countless other health problems, may no
longer be available. Just the information regarding importance of
healthy sleep and how and why melatonin helps correct those problems,
make the book one of great importance even a decade after publication!!!
When Dr. Russel Reiter explained to me during a conversation in
London (2004 First International Children With Leukaemia
Conference), that my husband, Bud, may never have developed
Alzheimers had he been taking melatonin all along, I thought he
understood my concerns about the electric clock radio and the
importance of moving it off Bud's nightstand, in addition to my giving
A review of the book, as mentioned above, clearly indicates he
"more than understood" and rather than addressing the issue of moving
the electric item away from the bed, he chose instead to emphasize
"consumption of melatonin." My hope at the time was that he
would share this vital information with others at the
conference. The three posters I was privileged to display
at the conference clearly expressed my overwhelming concerns regarding
close, nightime EMF/EMR exposures. Not everyone attending the
conference would have necessarily seen everyone's posters,
however. There were three separate display rooms.
Most of you know that Dr. Reiter was responsible for the press
release titled "Light at Night May Cause Cancer." Dr. Louis
Slesin later expressed his concerns about the lack of information to
the press re EMF's out of a conference that had so many important,
brilliant EMF researchers in attendance and more than a day of oral
presentations on the subject as well as the fact that the O'Gorman's
believe their son and daughter's cancers (Leukemia and breast
cancer) were causally related to EMF's from a substation in
Thinking back on all of this plus my review of Dr. Reiter's
book earlier tonight, causes me to strongly suspect Dr. Russel Reiter
has most likely been "restricted" from openly sharing both
his excitement about the benefits of taking melatonin as well as what
he has known for years about the adverse effects of reduced
melatonin levels. He also knows that EMF's from electrical
items -- especially at night -- adversely affect melatonin
I have mentioned numerous times how much melatonin has meant
to me re my own sleep and heightened level of energy, etc.
and also the fact that my husband Bud, no longer exhibits
confabulation, and delusional, angry events have ceased
completely. All of this, in addition to his improvement in three
areas of his Executive Function (neuropsych tests). He does,
however, still have serious memory problems and cognitive dysfunction
that I attribute primarily to sleeping close to an electric clock radio
(on nightstand) and taking statins (Lipitor) to lower his cholesterol
(cholesterol is actually offers "protection" to the brain -
I can't recommend strongly enough the importance of
everyone involved in the EMF cause reading this important book IF it
is possibly still available for
purchase. Take care
everyone - Joanne
Joanne C. Mueller
Guinea Pigs R Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota 55448-2127 USA
"Our frame of reference determines what we
look at and how we look. And as a consequence, this determines what we
find." Burke J, The Day
the Universe Changed, 1985.
ACTO BIOCHIMICA POLONICA
Vol. 54 No. 1/2007, 1–9
Melatonin and its metabolites: new findings
regarding their production
and their radical scavenging actions
Russel J. Reiter1, Dun-xian Tan1, M. Pilar Terron1,
Luis J. Flores1 and
1Department of Cellular and Structural Biology, University of Texas
Health Science Center at San Antonio, San
Antonio, USA, 2Department of Chemistry, University of Warsaw, Warszawa,
Received: 16 February, 2007; accepted: 27 February, 2007
available on-line: 09 March, 2007
This review summarizes some of the recent findings concerning the
long-held tenet that the enzyme,
N-acetyltransferase, which is involved in the production of
N-acetylserotonin, the immediate
precursor of melatonin, may in fact not always control the quantity of
New evidence from several different laboratories indicates that
which O-methylates N-acetylserotonin to melatonin may be rate-limiting
in some cases.
Also, the review makes the point that melatonin’s actions are
uncommonly widespread in organs
due to the fact that it works via membrane receptors, nuclear
receptors/binding sites and receptor-
independent mechanisms, i.e., the direct scavenging of free radicals.
Finally, the review briefly
summarizes the actions of melatonin and its metabolites in the detoxification
of oxygen and
nitrogen-based free radicals and related non-radical products. Via
these multiple processes, melatonin
is capable of influencing the
metabolism of every cell in the organism.
Keywords: antioxidant, free radicals, oxidative stress, electron
donation, melatonin synthesis
* ... most
of text and all references omitted...... *
CONCLUDING REMARKS: [....only small portion copied
below....jcm...5 30 07...]
".......Finally, whereas light
is certainly the major impeller of the circadian melatonin
rhythm, there is also controversial evidence
that suggests non-visible electromagnetic radiation
may influence the 24-hour rhythm of melatonin
(Lerchl et al., 1990).
Clearly, what enzyme is
important in the control of melatonin synthesis
may have to be re-evaluated. Indeed, the activity
of what enzyme actually determines melatonin synthesis
may depend on the physiological situation........."
[ Emphasis added by jcm...5 30 07....].