Betreff: EMF exp promotes tumor devel..same as ioniz rad 2000..EPRI/BC Hydro.....
Von: JCMPelican@aol.com
Datum: Sun, 6 May 2007 00:03:33 EDT



 
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Carcinogenesis, Vol. 21, No. 7, 1379-1389, July 2000
2000 Oxford University Press


Carcinogenesis

Hematopoietic neoplasia in C57BL/6 mice exposed to split-dose ionizing radiation and circularly polarized 60 Hz magnetic fields

Jane T. Babbitt1,9, Alexander I. Kharazi1,3, Jeremy M.G. Taylor4, Carole B. Bonds5, Stuart G. Mirell2,6, Emanuil Frumkin7, Dongliang Zhuang8 and Theodore J. Hahn1,7

1 Department of Medicine and
2 Department of Radiology, University of California at Los Angeles, Los Angeles, CA 90095,
3 Immunotherapy Laboratory, St Vincent's Medical Center, Los Angeles, CA 90057,
4 Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109,
5 Merle Norman Cosmetics, El Segundo, CA,
6 Nuclear Medicine and
7 Geriatric Research, Education and Clinical Center, V.A. Greater Los Angeles Healthcare System at West Los Angeles, Los Angeles, CA 90073 and
8 Scirex Corporation, Horsham, PA 19044, USA


    Abstract
 Top
 Abstract
 Introduction
 Materials and methods
 Results
 Discussion
 References
 
This study assessed the effect of chronic exposure to a 60 Hz circularly polarized magnetic field on the occurrence of ionizing radiation-induced lymphoma and other hematopoietic neoplasia in mice. Female C57BL/6 mice received lifetime exposure to either a magnetic field flux density of 1.42 mT for 18 h/day, or an ambient magnetic field of 0.13 T. Beginning on the first day of magnetic field exposure, 1710 mice were treated with one of three levels of split-dose Cobalt-60 {gamma}-radiation (cumulative 3.0, 4.0 or 5.1 Gy). The remaining 570 mice received sham irradiation treatment........

 
 
 
 
 
Ionizing radiation treatment effects
Mortality

Few deaths occurred before 18 months of age in untreated mice. Ionizing radiation treatment resulted in more and earlier deaths from all causes (Figure 1Go). Cause of death was not determined, and for most of the study, ~50% of the mice that died did not have a hematopoietic neoplasm present. However, almost all mice that died during the first year were diagnosed with radiation-induced thymic lymphoblastic lymphoma, which can reasonably be considered to be the cause of death (Figures 1 and 2GoGo). Deaths that might be attributable to acute radiation disease were rare. Of the 1710 irradiated mice, only 11 died within the first 100 days.........
 
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The data from this study suggest that tumor development is promoted in those animals which received only ionizing radiation treatment or only MF exposure. The data also suggest an interaction of ionizing radiation treatment effects and MF exposure effects in the development of radiation-induced thymic LB lymphomas. The mechanisms by which these two different levels of radiant energy affect tumor development remains to be determined, as does the mechanism of their interaction. Future studies to elucidate these relationships are warranted........
 
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This study was supported by research contracts W02965-03, W02965-11, W02965-31, W02965-33 and W02965-34 with the Electric Power Research Institute, Palo Alto, CA, with co-funding from BC Hydro.

Received November 23, 1999; revised March 27, 2000; accepted March 30, 2000.

References:   53 references with links to specific studies....

 
http://carcin.oxfordjournals.org/cgi/content/full/21/7/1379
 
 
[Emphasis added.....a long study.....only a couple portions copied above which are self-explanatory.  Of particular note, tho, is the small number of deaths compared to one out of each set of two guinea pigs exposed at our house to electric meter......the deaths in each instance, occurred in less than 30 days from time of exposure to electric meter.........jcm ..... 5-5-07....]