Betreff: Electrical pollution causing depression.
Von: Tetrawatch
Datum: Sun, 14 May 2006 17:40:57 +0100

I understand the email blizzard all too well, but I am including all, since I would value your response.
Most of you will be aware that I have been interested in the issue of EM fields disrupting nitric oxide synthase (NOS), with the consequence that physiological nitric oxide levels are disturbed, mostly elevated. This engenders a vicious cycle, the results of which correspond greatly with all we see in terms of EHS, immunological and neurological disorders. I have yet to come across any observed EM bio-effect that is not in some way mediated or regulated by NO.
So, as regards EMF and depression, here is the NO route:
Several studies have shown that EM fields do in fact disrupt the action of iNOS (inducible nitric oxide synthase), resulting in abnormal levels of nitric oxide:

Increase in nitric oxide and cyclic GMP of rat cerebellum by radio frequency burst-type electromagnetic field radiation.

by Miura M, Takayama K, Okada J, Miller JM, Jope RS, Ferraro TN, Hare TA; published in: J Physiol 1993; 461 : 513 524
Ultra-wideband pulses increase nitric oxide production by RAW 264.7 macrophages incubated in nitrate
Seaman RL, Parker JE, Kiel JL, Mathur SP, Grubbs TR, Prol HK; published in: Bioelectromagnetics 2002; 23 (1): 83 - 87
Pathophysiology. 2000 Jul;7(2):127-130
Pulsed magnetic fields enhance nitric oxide synthase activity in rat cerebellum.
Noda Y, Mori A, Liburdy RP, Packer L
Pathophysiology. 2000 Jul;7(2):131-135
Enhancement of nitric oxide generation by low frequency electromagnetic field.
Yoshikawa T, Tanigawa M, Tanigawa T, Imai A, Hongo H, Kondo M.
and so on... (all links go to abstracts)
Depression and nitric oxide:
Further Immunohistochemical Evidence for Impaired NO Signalling in the Hypothalamus of Depressed Patients
(Annals of the New York Academy of Sciences 973:91-93 (2002))
Surprising Links Between Depression, Suicide, Epilepsy
(re EMR and epilepsy, I collected some thoughts on the NO route here, at )
Low nNOS protein in the locus coeruleus in major depression.
(J Neurochem. 2004 Dec;91(5))
Nitric oxide synthase inhibitors have antidepressant-like properties in mice
Karolewicz B, Bruce KH, Lee B, Paul IA; Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216-4505, USA.  Eur J Pharmacol 1999 May 21; 372(3):215-20
Increased Plasma Nitric Oxide Metabolites in Suicide Attempters
Bun-Hee Lee, Sung-Woo Lee, Dokyung Yoon, Heon-Jeong Lee, Jong-Chul Yang, Se-Hoon Shim, Do-Hoon Kim, Seung-Ho Ryu, Changsu Han, Yong-Ku Kim
Neuropsychobiology 2006;53:127-132 (DOI: 10.1159/10.1159/000092542)
You can take it further from there, but I hope that introduces a line of thought.
Andy Davidson