Mutat Res. 2005 Aug 1;585(1-2):43-9. Related Articles,
Chromosomal damage in human diploid fibroblasts by intermittent
exposure to extremely low-frequency electromagnetic fields.
Ivancsits S, Pilger A, Adlkofer F, Rudiger HW.
Division of Occupational
Medicine, Medical University of Vienna, Wahringer Gurtel 18-20, Vienna A-1090,
Environmental exposure to extremely low-frequency
electromagnetic fields (ELF-EMFs) has been implicated in the development of
cancer in humans. An important basis for assessing a potential cancer risk due
to ELF-EMF exposure is knowledge of biological effects on human cells at the
chromosomal level. Therefore, we investigated in the present study the effect of
intermittent ELF electromagnetic fields (50Hz, sinusoidal,
5'field-on/10'field-off, 2-24h, 1mT) on the induction of micronuclei (MN) and
chromosomal aberrations in cultured human fibroblasts. ELF-EMF radiation
resulted in a time-dependent increase of micronuclei, which became significant
after 10h of intermittent exposure at a flux density of 1mT. After approximately
15h a constant level of micronuclei of about three times the basal level was
reached. In addition, chromosomal aberrations were increased up to 10-fold above
basal levels. Our data strongly indicate a clastogenic potential of intermittent
low-frequency electromagnetic fields, which may lead to considerable chromosomal
damage in dividing cells.
Montag, 8. August 2005, 15:38 - Rubrik: Wissenschaft zu