Betreff: Alzheimers...memory improvement re histone acetylation.....

Von: JCMPelican

Datum: Fri, 8 Jun 2007 11:41:57 EDT




Re:   Alzheimers....memory improvement re histone acetylation.....


I am forwarding separately information regarding a new study re histone acetylation as well as relevant  studies from 1998 and 2002.  


Assoc. Prof. Olle Johansson has conducted hundreds of EMF studies that relate either directly or indirectly to findings re immune deficiencies as well as Alzheimers and other health problems.   As most persons involved in reviewing journal articles re effects of EMF/EMR know, "histamine" plays a very important role.


Here  are a couple of comments from previously posted information on Omega site below:



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Portions of email exchanges between Assoc. Prof. Olle Johansson and Joanne Mueller (2005) re skin problems and lack of IgE findings in EHS (electrohypersensitive) patients and comparisons re rare IGG subclass deficiencies:   


"........We would favour studies of electromagnetic fields' interaction with mast cell release of histamine and other biologically active substances, studies of lymphocyte viability as well as studies of the newly described serotonin-containing well as other markers for cell traffic, proliferation and inflammation.......such scientific work may lay a firm foundation for necessary adjustment of accessibility, thus helping and supporting all persons with the impairment electrohypersensitivity......." .olle johansson Oct. 2005


" ........ a 'very important evaluation'  that will hopefully go a long way toward moving away from "allergic-type sensitivity" to deal with the "
real issue of EMF/EMR-induced toxicity" -- or "the poisoning" that results from chronic, prolonged exposures to even low levels of electromagnetic radiation pollution......!!!!   joanne mueller Oct. 2005

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See also list of references:


Assoc. Prof. Olle Johansson, Karolinska Institute, Stockholm Sweden



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I call specific attention to the following study re the need to consider all EMF/EMR exposures as contributors to the sort of stresses that are reported to be associated with memory decline:


Hallberg Ö, Johansson O, "Alzheimer mortality - why does it increase so
fast in sparsely populated areas?", Europ Biol Bioelectromag 2005; 1:


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The knowledge exists -- studies support what is known and future studies will provide even more conclusive results.    My appeal continues for the publicity needed to "fuel the fires" that will help generate the much-needed funding for Assoc. Prof. Olle Johansson in turning these tragic events around!!!!  


Take care everyone    -    Joanne


  Joanne C. Mueller
Guinea Pigs R Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota  55448-2127 USA
Phone:   763-755-6114
Email:   (6-08-07)


All truth goes through three stages: first it is ridiculed:
then it is violently opposed: finally it is accepted as self evident.  - Schopenhauer


"The things that will destroy us are: politics without principle; pleasure without conscience; wealth without work; knowledge without character; business without morality; science without humanity; and worship without sacrifice."

--Mahatma Gandhi



Alz...histone acetylation...2007 Von: Datum: Fri, 8 Jun 2007 10:32:22 EDT An:

Journal Watch General Medicine Alert General Medicine for June 7, 2007 Drugs and Mental Exercises Enhance Recovery of Lost Memories in Mice

Summary and Comment | Subscription Required

The key to both approaches was an increase in histone acetylation.

By Anthony L. Komaroff, MD

June 7, 2007

Covering: Fischer A et al. Nature 2007 May 10; 447:178-82



Date: Fri, 8 Jun 2007 10:29:45 EDT




Vol. 12, No. 5, pp. 599-606, March 1, 1998

Histone acetylation and transcriptional regulatory mechanisms

Kevin Struhl1

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115 USA




More than 30 years ago, Vincent Allfrey proposed that histone acetylation was associated with transcriptional activity in eukaryotic cells (Allfrey et al. 1964; Pogo et al. 1966). Subsequently, acetylated core histones were shown to preferentially associate with transcriptionally active chromatin (Sealy and Chalkley 1978; Vidali et al. 1978; Hebbes et al. 1988). Acetylation occurs at lysine residues on the amino-terminal tails of the histones, thereby neutralizing the positive charge of the histone tails and decreasing their affinity for DNA (Hong et al. 1993). As a consequence, histone acetylation alters nucleosomal conformation (Norton et al. 1989), which can increase the accessibility of transcriptional regulatory proteins to chromatin templates (Lee et al. 1993; Vettese-Dadey et al. 1996). Taken together, these observations suggested how histone acetylation could result in increased transcriptional activity in vivo. However, there was essentially no information about the cause and effect relationship between histone acetylation and transcriptional activity or about the underlying molecular mechanisms.......

.[ Alz file ....this is a lengthy, very important article --  review in conjunction with other articles re histone acetylation and memory improvement ......jcm....6-08-07.....]




Alz...HISTONE ACETYLATION (imprv memory)....


Date: Fri, 8 Jun 2007 10:18:07 EDT






EMBO reports 3, 3, 224–229 (2002)




Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin

Karl P. Nightingale1, Ralf E. Wellinger2, Jose M. Sogo2 and Peter B. Becker1

1 Gene Expression Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
2 Institut für Zellbiologie, ETH-Hönggerberg, CH-8093 Zürich, Switzerland

To whom correspondence should be addressed
Peter B. Becker,

Received 28 January 1998; Revised 17 March 1998; Accepted 17 March 1998.


A number of activators are known to increase transcription by RNA polymerase (pol) II through protein acetylation. While the physiological substrates for those acetylases are poorly defined, possible targets include general transcription factors, activator proteins and histones. Using a cell-free system to reconstitute chromatin with increased histone acetylation levels, we directly tested for a causal role of histone acetylation in transcription by RNA pol II. Chromatin, containing either control or acetylated histones, was reconstituted to comparable nucleosome densities and characterized by electron microscopy after psoralen cross-linking as well as by in vitro transcription. While H1-containing control chromatin severely repressed transcription of our model hsp26 gene, highly acetylated chromatin was significantly less repressive. Acetylation of histones, and particularly of histone H4, affected transcription at the level of initiation. Monitoring the ability of the transcription machinery to associate with the promoter in chromatin, we found that heat shock factor, a crucial regulator of heat shock gene transcription, profited most from histone acetylation. These experiments demonstrate that histone acetylation can modulate activator access to their target sites in chromatin, and provide a causal link between histone acetylation and enhanced transcription initiation of RNA pol II in chromatin.

Keywords: chromatin, heat shock, histone acetylation, nucleosomes, transcription

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[  .....  Alzheimers file notes:  review re following study "recovery lost memories in mice" (subscr required) when accessed......emphasis in article "Histone acetylation"  -- EMBO reports 3, 3, 224–229 (2002)

doi:10.1093/embo-reports/kvf053 added jcm 6-08-07..... ]

Drugs and Mental Exercises Enhance Recovery of Lost Memories in Mice

Summary and Comment | Subscription Required

The key to both approaches was an increase in histone acetylation.

By Anthony L. Komaroff, MD

June 7, 2007

Covering: Fischer A et al. Nature 2007 May 10; 447:178-82