Betreff: AUTISM...abnormal melatonin synthesis....2007
Datum: Mon, 28 May 2007 02:35:49 EDT

It seems inconceivable to me that the forwarded study titled  "Abnormal melatonin synthesis in autism spectrum disorders" would not include some sort of evaluation regarding nighttime EMF/EMR exposures.   While the study acknowledges that low levels of melatonin have been reported in individuals with autism spectrum disorders, the abstract indicates  "....underlying cause of this deficit was unknown....."
The abstract refers to the ASMT gene as "encoding the last enzyme of melatonin synthesis..."
A review of the entire study may yield other important facts since the authors state   "....highlight the crucial role of melatonin in human cognition and behavior......"  
Facts in this study are obviously also relevant in regard to Alzheimers' Disease which involves many years of increasing cognitive decline and behavioral problems that usually lead to need to place patients in secured nursing home facilities.  
Whether autism or Alzheimers, the problems and costs to patients, caregivers, as well as to society, that result from not dealing openly with probable causes of melatonin decline, are enormous and tragic!!! 
I simply refuse to accept the "lame excuse" that "underlying cause of this deficit was unknown.  I do believe that "the cause" was more likely than not "deliberately excluded" from the study........  
Best wishes to everyone for "a better tomorrow....."       Joanne
Joanne C. Mueller
Guinea Pigs R Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota  55448-2127 USA
Phone:   763-755-6114
Email:  (5-28-07)
All truth goes through three stages: first it is ridiculed:
then it is violently opposed: finally it is accepted as self evident.  - Schopenhauer
"The things that will destroy us are: politics without principle; pleasure without conscience; wealth without work; knowledge without character; business without morality; science without humanity........"
--Mahatma Gandhi

1: Mol Psychiatry. 2007 May 15; [Epub ahead of print]Click here to read  Links

Abnormal melatonin synthesis in autism spectrum disorders.

1Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France.

Melatonin is produced in the dark by the pineal gland and is a key regulator of circadian and seasonal rhythms. A low melatonin level has been reported in individuals with autism spectrum disorders (ASD), but the underlying cause of this deficit was unknown. The ASMT gene, encoding the last enzyme of melatonin synthesis, is located on the pseudo-autosomal region 1 of the sex chromosomes, deleted in several individuals with ASD. In this study, we sequenced all ASMT exons and promoters in individuals with ASD (n=250) and compared the allelic frequencies with controls (n=255). Non-conservative variations of ASMT were identified, including a splicing mutation present in two families with ASD, but not in controls. Two polymorphisms located in the promoter (rs4446909 and rs5989681) were more frequent in ASD compared to controls (P=0.0006) and were associated with a dramatic decrease in ASMT transcripts in blood cell lines (P=2 x 10(-10)). Biochemical analyses performed on blood platelets and/or cultured cells revealed a highly significant decrease in ASMT activity (P=2 x 10(-12)) and melatonin level (P=3 x 10(-11)) in individuals with ASD. These results indicate that a low melatonin level, caused by a primary deficit in ASMT activity, is a risk factor for ASD. They also support ASMT as a susceptibility gene for ASD and highlight the crucial role of melatonin in human cognition and behavior.Molecular Psychiatry advance online publication, 15 May 2007; doi:10.1038/

PMID: 17505466 [PubMed - as supplied by publisher]