Epidemiology. 2007
Jan;18(1):158-161.
Magnetic Fields and Acute Leukemia in Children With
Down Syndrome.
·
Gorodezky C,
From the *Epidemiologia, Clinica,
Hospital de Pediatria, Centro Medico Nacional, Siglo XXI, Instituto Mexicano
del Seguro Social (IMSS), Mexico; daggerInmunogenetica, Instituto de
Diagnostico y Referencia Epidemiologicos, Secretaria de Salud (SSa), Mexico;
double daggerOnco-Hematologia, Hospital Infantil de Mexico Federico Gomez, SSa,
Mexico; section signHematologia, Instituto Nacional de Pediatria, SSa, Mexico;
paragraph signHematologia, Hospital General, Centro Medico Nacional La Raza,
IMSS, Mexico; parallelGenetica, Hospital de Pediatria Centro Medico Nacional Siglo
XXI, IMSS, Mexico; and **Jefatura de Investigacion, Instituto Nacional de
Neurologia, SSa, Mexico.
BACKGROUND:: We analyzed
effects of exposure to magnetic fields on the expression of acute leukemia in
children with Down syndrome (who have a 20-fold higher risk of leukemia). METHODS::
We performed a case-control study that included 42 children with both acute
leukemia and Down syndrome as cases and 124 healthy children with Down syndrome
as controls. We obtained demographic information concerning the children and
took spot measurements of magnetic fields at each residence. RESULTS:: The odds
ratio for direct measurements of magnetic fields >/=6.00 mG was 3.7 (95%
confidence interval = 1.05-13.1). CONCLUSION:: The association between magnetic
fields and leukemia in children with Down syndrome suggests the possibility of
a causal role for magnetic fields in the etiology of leukemia among a
genetically susceptible subgroup of children.
PMID: 17099322 [PubMed - as
supplied by publisher]
---------------------------------------------------------------------------------------------------------------------------
Text below machinable
translated from Spanish in English:
SYNDROME OF
DOWN AND LEUKEMIA ASSOCIATED TO THE EXHIBITION TO CEM
I feel it, is Christmas but this New work opens an old debate, at least for me. Memory, that a year ago in the court of Estella (Navarrese) acting like expert of the accusation of neighbors affected by a transformer of Iberdrola, inlaid underneath its houses, I presented/displayed an additional report. This one was based on a very significant aspect of the REFLEX, or the possible greater genotoxicidad or greater risk for example of cancer between those people with manifest genetic alterations as the “Ataxia Teleangiectasia” Thus, said part of my report on REFLEX: “Of this form, 100 inferior cm to microteslas, under the indicated experimental conditions produced significant changes not only in the chemical structure of the DNA (genotoxicidad), but in kinetic of division or the cellular proliferation, apoptosis (cellular death) or answer as opposed to growth factors, that negatively depended on the age of the donor or less capacity of repair of the DNA or its pathology (Ataxia Telangiectasia)” Naturally, these results are presumably extrapolables to any other pathology genetic as therefore it it has corroborated a work published in Epidemiology, indicating that young with syndrome of Down (SD) that live in atmospheres with electromagnetic fields (CEM) of VLF (ELF) (electrical lines (high and average tension, transforming loss in viendas) over single 0.6 microteslas have 3.7 times of average more risk to undergo leukemia that young with this syndrome and that lives under a smaller CEM. The number of studied cases, young with SD + leukemia enough is elevated if we consider the Karolinska study, in front of 124 healthy children with SD. So and as this study remembers to us the children with SD have of average 20 times more of possibilities than without SD to suffer a leukemia throughout its life unfortunately, thus constituting a model of susceptibility to this cancer and interest like model in studies on environmental risks related to that disease. Another possible association also corroborated recently, comes derived from the exhibition from the mother during the gestation to the CEM, increasing therefore the risk of suffering a leukemia to its children in the future. Thus, two last reflections before concluding this year about the possible favorecedor mechanism of a leukemia in children or adults derived from the maternal exhibition to CEM and the suffering of serious genetic alterations or that are expressed fenotípicamente. Anyone can introduce in GOOGLE the key words, genetic diseases finding an ample list from the multiple sclerosis (a 15% affected relatives) to the muscular dystrophies, happening clear through the syndrome of Down, hemofilia… Genotóxicas REFLEX really find alteration very below which the law considers like level of reference or 100 microteslas, but already we see that that limit is intolerable, cellular, clinically and therefore ethically; and much more if we considered to single the patients with genetic anomalies towards which one would be due to contemplate to establish any environmental average norm, unless we want that single the forts survive. Dr Claudius Go'mez-Perretta Research center, Hospital the Faith 46009 Valencia PS: This small writing I want that humbly it serves as tribute for a mother fighter by the memory and justice of its Jairo son, whose story of life and disappearance has filled us of sadness all. We will never know if its cerebral tumor had to the strong CEM that underwent their house, more than 0.4 microteslas (it underneath had and it has a powerful electrical transformer) in its small dormitory, but that this fact is at sight of the INTOLERABLE present scientific knowledge and it will not never be able to discard either, its possible influence on the terrible disease of its son. JAIRO GOES BY YOU Bibliography: Magnetic Fields and Acute Leukemia in Children With Down Syndrome. Published in Epidemiology. 18 (1): 158-161, January 2007 Maternal Occupational Exposure to ELF Magnetic Fields During, Pregnancy and Childhood Leukemia Published in Epidemiology, Vol. 14, 2003