Betreff: Fwd: ALZHEIMERS..degeneration...changes in electrical properties of cells...

Von: JCMPelican @aol.com

Datum: Tue, 26 Jun 2007 22:16:41 EDT

ALZHEIMERS....RE DEGENERATION DUE TO CHANGES IN ELECTRICAL PROPERTIES OF CELLS

To: World Health Organization and EMF-activist List: I have emphasized certain parts of the forwarded study re protein misfolding and amyloid.

Research uncovered after my guinea pig, Kelley's diagnosis: "Reactive Renal Amyloidosis" (chronic, prolonged exposure to electric meter), prompted me to quickly learn as much as possible about the folding/misfolding/unfolding of proteins. I have located many related studies.

I was disheartened to learn that "the powers-that-be" apparently have no intentions of letting the public know that chronic, prolonged, low level EMF/EMR exposures are related to the formation of "toxic amyloid." "Big Pharma" is attempting yet another drug to deal with problems "after-the-fact" instead of contributing their knowledge toward helping to resolve major, world-wide healthcare issues due in large part to the public not being informed re EMF/EMR prudent avoidance recommendations. I had great hope that change was forthcoming when I discovered reseach facts re high priorities being placed on protein folding research by the U.S. National Institute of Health........ Joanne

Joanne C. Mueller
Guinea Pigs R Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota 55448-2127 USA
Phone: 763-755-6114
Email: jcmpelican@aol.com (6-26-07)

You can chase a dream
That seems so out of reach
And you know it might not ever come your way
Dream it anyway .....Song "Anyway"...Martina McBride & Warren Brothers

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NEWS-MEDICAL.NET

New understanding of degeneration of brain cells in patients with Alzheimer's, Huntington's, and Parkinson's diseases

Medical Research News

Published: Monday, 11-Jul-2005

A ground-breaking new research approach to understanding the cellular processes of Alzheimer's and other degenerative diseases has revealed a promising pathway to the development of new types of drugs for these diseases.

The discovery, made in the laboratory of Ratnesh Lal, research scientist in the Neuroscience Research Institute (NRI) at the University of California, Santa Barbara, is published in this week's online issue of the Proceedings of the National Academy of Sciences (PNAS).

The research describes a new way of understanding the degeneration of brain cells in patients with Alzheimer's, Huntington's, and Parkinson's diseases, as well as other degenerative diseases. Misfolded proteins in the cell membrane, and subsequent changes in the electrical properties of cells, provide the explanation for the cell degeneration. Specific three-dimensional structures of misfolded proteins are embedded in the cell membrane.

"It has long been thought that amyloid plaque, which has been studied for 30 years, was the cause of Alzheimer's disease," said Lal. "Plaque isn't the cause." He explained that the fibers of plaque are too large to directly affect small cells.

The answers may come from small globs of misshapen, misfolded proteins that make well-defined holes in cell membranes and disrupt their electrical activity, according to the study.

Amyloid protein is a sticky, globular substance created when normal cellular proteins become twisted and contorted into abnormal shapes. While amyloid formation has been associated with diseases like Alzheimer's, Parkinson's, and Huntington's, scientists have puzzled over whether and how it actually kills cells and causes disease. To gain insight into this mysterious process, Lal and his research team examined the three-dimensional structure of several different proteins associated with these diseases. The researchers observed that all of the proteins folded into structures resembling ion channels, or pores within cell membranes. These pores control the electrical properties of the cell by regulating the flow of charged particles (ions) such as calcium.

When embedded into artificial membranes, the misfolded proteins were able to produce electrical currents, confirming their similarity to ion channels. Since abnormal ion balance is known to disrupt cell function and cause degeneration, these results provide proof of a possible mechanism by which amyloid formation may lead to the cellular destruction seen in these neurodegenerative diseases.

"These ion channels could serve as a model system for designing preventive and therapeutic drugs," said Lal. "You don't need large aggregates of these amyloid proteins, the plaque, to have this disruption. Rather, small aggregates, when in contact with membrane, form ion channels and allow passage of ion current. By controlling activity and designing specific drugs to regulate these channels, we might be able to prevent and/or treat various diseases related to the amyloids."

These findings provide a major piece of the puzzle about the underlying protein misfolding associated with these degenerative diseases. Besides the diseases already mentioned, other degenerative diseases that also result from misfolded proteins include cystic fibrosis, type II diabetes, cerebrovascular dementia, arthritis, tuberculosis, as well as British and Danish famial dementias.

The researchers used atomic force microscopy (AFM) to view the ion channels. By using the AFM they were able to view these "bio-nano" molecules. The AFM allows for a look at these very small channels, which would be very difficult if not impossible to see in their native, cell-like environment with electron microscopy.

In addition to Lal, the authors of this path-breaking paper are: Arjan Quist and Ivo Doudevski of the NRI at UCSB; Han Lin of the University of Pittsburgh; Rushana Azimova and Bruce Kagan of the University of California, Los Angeles; and Douglas Ng, Blas Frangione, and Jorge Ghiso of New York University.

http://www.ucsb.edu/

http://www.news-medical.net/?id=11611

PATENT TO MEASURE COGNITIVE IMPAIRMENT -

According to patent (access info below) for purpose of measuring cognitive impairment, "radiation is radiation....." I have copied below only a few of the items of concern cited in the patent application.

A search of the first inventor's name brings up a website for a specialized agency of the United Nations, referred to as "WIPO." [ http://www.wipo.int/pctdb/en/wo.jsp?wo=2001072217 ] ".......WIPO is dedicated to developing a balanced and accessible international intellectual property (IP) system, which rewards creativity, stimulates innovation and contributes to economic development while safeguarding the public interest......". International patent registration details are on the WIPO website although the U.S. patent info I copied below is not displayed. Info re the international patent applicant is:

Applicant:

PANMEDIX INCORPORATED [US/US]; 2nd floor, 15 Maiden Lane, New York, NY 10038 (US).

I know that the rare immune deficiencies in my two grandsons due to electric meter exposures as well as electric meter exposures re my two guinea pig studies, yielded results that are "consistent with markers for ionizing radiation......" The rare bone marrow problem " Reactive Renal Amyloidosis " was also identified during necropsy of one guinea pig. "Amyloid plaque" is often identified during autopsy of Alzheimers' patients.

My husband's profound and unusual memory loss and cognitive dysfunction that eventually turned to a diagnosis of "Alzheimers" (after many years of testing showing decline), improved significantly after moving his electric clock radio off his nightstand, discontinuing statins and starting him on melatonin (and other vitamins and supplements). As I have also recently reported, my husband no longer has delusions and hallucinations and he also doesn't wake up in an agitated/angry, confused state-of-mind.

The importance of these facts, while usually considered to be "anecedotal," are, in fact, supported by many blood tests and also "documented improvement" in three areas of Executive Function re my husband. These "vital facts" should not be arbitrarily dismissed! The "world-wide dilemma regarding dramatic increases in autism, ADD, ADHD, learning problems, Alzheimers and other neurodegenerative disorders, can not wait for animal studies. We must announce "prudent avoidance recommendations" re close, chronic prolonged EMF/EMR exposures to electric "bedroom appliances" and some telephone equipment now!!! Who will be "a voice for the people?" Take care everyone - Joanne

Joanne C. Mueller
Guinea Pigs R Us
731 - 123rd Avenue N.W.
Minneapolis, Minnesota 55448-2127 USA
Phone: 763-755-6114
Email: jcmpelican@aol.com (6-26-07)

All truth goes through three stages: first it is ridiculed:
then it is violently opposed: finally it is accepted as self evident. - Schopenhauer

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Title:

Measuring cognitive impairment

Document Type and Number:

United States Patent 6964638

Link to this page:

http://www.freepatentsonline.com/6964638.html

Abstract:

System (s100, s200, s300, s400) to quantify cognitive performance

Inventors:

Theodoracopulos, Alexis (New York, NY, US)
Kaplan, Darin (New York, NY, US)
Shchogolev, Vladislav (Brooklyn, NY, US)
Erlanger, David M. (New York, NY, US)
Yee, Philip (New York, NY, US)
Comrie, McDonald (Staten Island, NY, US)

Application Number:

239383

Filing Date:

01/23/2001

Publication Date:

11/15/2005

Assignee:

Pan Medix, Inc. (New York, NY)

View Patent Images:

Images are available in PDF form when logged in. To view PDFs,

14. The method of claim 1, wherein the method is used to quantify the cognitive impairment associated with excessive exposure to radiation.

15. The method of claim 14, wherein said radiation comprises electric shock.

16. The method of claim 14, wherein said radiation comprises sunlight.

17. The method of claim 14, wherein said radiation comprises ambient electromagnetic radiation due to an electromagnetic device.